On Paper Diagnostics for Infectious Agents using Nanobes (Specific Aptamers) which Could Be Used for Rapid Home Diagnosis of SARS-CoV-2 (in saliva) or Adapted Rapidly for New Emerging Biological Agents (May 2015 Longitude Prize Submission)

All the previous Nanobe posts have led to this one to show how the nanotechnology could be applied to the COVID-19 crisis. Aptamers against SARS-CoV-2 have already been made (Yanling Song et al. Discovery of Aptamers Targeting the Receptor-Binding Domain of the SARS-CoV‐2 Spike Glycoprotein. Anal. Chem. 2020, 92, 9895−9900; from China; unlike the US DoD, they have not abandoned this technology). Nanobes could be extended from diagnostics to treatment to autogenous vaccine by immune response redirection as it was intended to do for bio dense against agents that threaten the military where solutions need to be applied to as close as possible to the threat rapidly, even in non-permissive territories under the most primitive and restrictive conditions. The example above was designed for bacteria, not just viruses, to determine viability and antibiotic/antimicrobial sensitivity. A single virus diagnostic, as for SARS-CoV-2, would be a much simpler design.

The Department of Homeland Security is having a industry day today for Mediao Advisory: DHS to Hold Virtual Industry Day Seeking Innovative Solutions for Coronavirus Response. However, they have chosen to exclude nanotechnology and biotechnology, like that described in this blog and already vested in by the US government but abandoned. These are already poised to solve the problems addressed in their solicitation: The topic call is seeking commercially available technology solutions to address the following pandemic-related needs

• Testing & validation to ensure data privacy standards across contact tracing apps
• Video analytics for self-service TSA checkpoints
• Rapid sanitization of large surfaces
• Data aggregation across authoritative and non-authoritative sources
• Enhanced point-of-entry screening methods at DHS facilities

Solicitation: https://lnks.gd/l/eyJhbGciOiJIUzI1NiJ9.eyJidWxsZXRpbl9saW5rX2lkIjoxMDUsInVyaSI6ImJwMjpjbGljayIsImJ1bGxldGluX2lkIjoiMjAyMDA4MTEuMjU1NDQxMjEiLCJ1cmwiOiJodHRwczovL2dvLnVzYS5nb3YveGZYN2EifQ.DBvAWTJlhXUPzu7IAfHU5MZE8hEuH4-oApyKhZzpvHY/s/86442368/br/82210981199-l.

Tuesday, August 18, 2020

09:30 a.m. – 1:00 p.m. PT – Department of Homeland Security staff will discuss mission challenges, technology needs and doing business with SVIP. Speakers include: Melissa Oh, SVIP Managing Director, DHS S&T; Anil John, SVIP Technical Director, DHS S&T; John Fortune, Screening at Speed Program Manager, DHS S&T; Teresa Quitugua, Deputy Director, National Biosurveillance Integration Center (NBIC); William Pharis, Program Manager, DHS S&T; Kevin Grottle, Program Manager, DHS S&T.